Volume 4, Number 1, March 2007

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus
Justin MS Lee, Cheerag Shirodaria, Clare E Jackson, Matthew D Robson, Charalambos Antoniades, Jane M Francis, Frank Wiesmann, Keith M Channon, Stefan Neubauer, Robin P Choudhury

Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10^-3 vs. 3.5 x 10^-3 mmHg^-1, p<0.01), faster PWV (8.8 vs., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs. 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy.

Diabetes Vasc Dis Res 2007;4:44-48.

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